Publications

2025

  • Nikolic N, Pleška M, Bergmiller T, Guet CC. 2025. A bacterial toxin–antitoxin system as a native defence element against RNA phages. Biol. Lett. 21: 20250080. 10.1098/rsbl.2025.0080

[pdf]

  • Jain K, Hauschild R, Bochkareva OO, Roemhild R, Tkačik G, Guet CC. 2025. Pulsatile basal gene expression as a fitness determinant in bacteria. Proc Natl Acad Sci U S A 122(15):e2413709122. 10.1073/pnas.2413709122

[pdf]

  • Grah R, Guet CC, Tkačik G, Lagator M. 2025. Linking molecular mechanisms to their evolutionary consequences: a primer. Genetics 229(2):iyae191. 10.1093/genetics/iyae191

[pdf]

2023

  • Guet CC, Bruneaux L, Oikonomou P, Aldana M, Cluzel P. 2023. Monitoring lineages of growing and dividing bacteria reveals an inducible memory of mar operon expression. Frontiers in Microbiology 14, 1049255. 10.3389/fmicb.2023.1049255[pdf]

2022

  • Tomasek K, Leithner A, Glatzova I, Lukesch MS, Guet CC, Sixt M. 2022. Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14. Elife 11:e78995. 10.7554/eLife.78995[pdf]
  • Tomanek I, Guet CC. 2022. Adaptation dynamics between copy-number and point mutations. Elife 11:e82240. 10.7554/eLife.82240[pdf]
  • Lagator M*, Sarikas S*, Steinrück M, Toledo-Aparicio D, Bollback JP, Guet CC*, Tkačik G*. 2022. Predicting bacterial promoter function and evolution from random sequences. Elife 11:e64543. 10.7554/eLife.64543 [pdf]

2021

  • Nagy-Staron A, Tomasek K, Caruso Carter C, Sonnleitner E, Kavčič B, Paixão T, Guet CC. 2021. Local genetic context shapes the function of a gene regulatory network. Elife 10:e65993. 10.7554/eLife.65993[pdf]
  • Petrov T, Igler C, Sezgin A, Henzinger TA, Guet CC. 2021. Long lived transients in gene regulation. Theoretical Computer Science 893:1–16. 10.1016/j.tcs.2021.05.023[pdf]

2020

  • Zisis T, Schwarz J, Balles M, Kretschmer M, Nemethova M, Chait R, Hauschild R, Lange J, Guet C, Sixt M, Zahler S. 2021. Sequential and Switchable Patterning for Studying Cellular Processes under Spatiotemporal Control. ACS Appl Mater Interfaces 13:35545–35560. 10.1021/acsami.1c09850 pdf]
  • Tomanek I, Grah R, Lagator M, Andersson AMC, Bollback JP, Tkačik G, Guet CC. 2020. Gene amplification as a form of population-level gene expression regulation. Nat Ecol Evol 4:612–625. 10.1038/s41559-020-1132-7 [pdf]

2019

  • Ruess J, Pleška M, Guet CC, Tkačik G. 2019. Molecular noise of innate immunity shapes bacteria-phage ecologies. PLoS Comput Biol 15:e1007168. 10.1371/journal.pcbi.1007168 [pdf]

2018

  • Chaudhry WN, Pleška M, Shah NN, Weiss H, McCall IC, Meyer JR, Gupta A, Guet CC, Levin BR. 2018. Leaky resistance and the conditions for the existence of lytic bacteriophage. PLoS Biol 16:e2005971. 10.1371/journal.pbio.2005971 [pdf]
  • De Martino D, Mc Andersson A, Bergmiller T, Guet CC, Tkačik G. 2018. Statistical mechanics for metabolic networks during steady state growth. Nat Commun 9:2988. 10.1038/s41467-018-05417-9 [pdf]
  • Igler C, Lagator M, Tkačik G, Bollback JP, Guet CC. 2018. Evolutionary potential of transcription factors for gene regulatory rewiring. Nat Ecol Evol 2:1633–1643. 10.1038/s41559-018-0651-y [pdf]
  • Pleška M, Lang M, Refardt D, Levin BR, Guet CC. 2018. Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity. Nat Ecol Evol 2:359–366. 10.1038/s41559-017-0424-z [pdf]
  • Tomasek K, Bergmiller T, Guet CC. 2018. Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. J Biotechnol 268:40–52. 10.1016/j.jbiotec.2018.01.008 [pdf]

2017

  • Barone V, Lang M, Krens SFG, Pradhan SJ, Shamipour S, Sako K, Sikora M, Guet CC, Heisenberg C-P. 2017. An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Dev Cell 43:198-211.e12. 10.1016/j.devcel.2017.09.014 [pdf]
  • Bergmiller T, Andersson AMC, Tomasek K, Balleza E, Kiviet DJ, Hauschild R, Tkačik G, Guet CC. 2017. Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. Science 356:311–315. 10.1126/science.aaf4762 [pdf]
  • Chait R, Ruess J, Bergmiller T, Tkačik G, Guet CC. 2017. Shaping bacterial population behavior through computer-interfaced control of individual cells. Nat Commun 8:1535. 10.1038/s41467-017-01683-1 [pdf]
  • Giacobbe M, Guet CC, Gupta A, Henzinger TA, Paixão T, Petrov T. 2017. Model checking the evolution of gene regulatory networks. Acta Informatica 54:765–787. 10.1007/s00236-016-0 [pdf]
  • Lagator M, Paixão T, Barton NH, Bollback JP, Guet CC. 2017a. On the mechanistic nature of epistasis in a canonical cis-regulatory element. Elife 6:e25192. 10.7554/eLife.25192 [pdf]
  • Lagator M, Sarikas S, Acar H, Bollback JP, Guet CC. 2017b. Regulatory network structure determines patterns of intermolecular epistasis. Elife 6:e28921. 10.7554/eLife.28921 [pdf]
  • Pleška M, Guet CC. 2017. Effects of mutations in phage restriction sites during escape from restriction-modification. Biol Lett 13:20170646. 10.1098/rsbl.2017.0646 [pdf]
  • Renault TT, Abraham AO, Bergmiller T, Paradis G, Rainville S, Charpentier E, Guet CC, Tu Y, Namba K, Keener JP, Minamino T, Erhardt M. 2017. Bacterial flagella grow through an injection-diffusion mechanism. Elife 6:e23136. 10.7554/eLife.23136 [pdf]
  • Steinrueck M, Guet CC. 2017. Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. eLife 6:e25100. 10.7554/eLife.25100 [pdf]

2016

  • Friedlander T, Prizak R, Guet CC, Barton NH, Tkačik G. 2016. Intrinsic limits to gene regulation by global crosstalk. Nat Commun 7:12307. 10.1038/ncomms12307 [pdf]
  • Lagator M, Igler C, Moreno AB, Guet CC, Bollback JP. 2016. Epistatic Interactions in the Arabinose Cis-Regulatory Element. Mol Biol Evol 33:761–769. 10.1093/molbev/msv269 [pdf]
  • Pleška M, Qian L, Okura R, Bergmiller T, Wakamoto Y, Kussell E, Guet CC. 2016. Bacterial Autoimmunity Due to a Restriction-Modification System. Current Biology 26:404–409. 10.1016/j.cub.2015.12.041 [pdf]

2012

  • Hadizadeh Yazdi N, Guet CC, Johnson RC, Marko JF. 2012. Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions. Mol Microbiol 86:1318–1333. 10.1111/mmi.12071 [pdf]

2011

  • Park H, Guet CC, Emonet T, Cluzel P. 2011a. Fine-tuning of chemotactic response in E. coli determined by high-throughput capillary assay. Curr Microbiol 62:764–769. 10.1007/s00284-010-9778-z [pdf]
  • Park H, Oikonomou P, Guet CC, Cluzel P. 2011b. Noise underlies switching behavior of the bacterial flagellum. Biophys J 101:2336–2340. 10.1016/j.bpj.2011.09.040 [pdf]

2010

  • Park H, Pontius W, Guet CC, Marko JF, Emonet T, Cluzel P. 2010. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature 468:819–823. 10.1038/nature09551 [pdf]

2008

  • Guet CC, Bruneaux L, Min TL, Siegal-Gaskins D, Figueroa I, Emonet T, Cluzel P. 2008. Minimally invasive determination of mRNA concentration in single living bacteria. Nucleic Acids Res 36:e73. 10.1093/nar/gkn329 [pdf]
  • Kinkhabwala A, Guet CC. 2008. Uncovering cis regulatory codes using synthetic promoter shuffling. PLoS One 3:e2030. 10.1371/journal.pone.0002030 [pdf]

2006

  • Le TT, Emonet T, Harlepp S, Guet CC, Cluzel P. 2006a. Dynamical determinants of drug-inducible gene expression in a single bacterium. Biophys J 90:3315–3321. 10.1529/biophysj.105.073353 [pdf]
  • Le TT, Guet CC, Cluzel P. 2006b. Protein expression enhancement in efflux-deleted mutant bacteria. Protein Expr Purif 48:28–31. 10.1016/j.pep.2005.11.018 [pdf]

2005

  • Le TT, Harlepp S, Guet CC, Dittmar K, Emonet T, Pan T, Cluzel P. 2005. Real-time RNA profiling within a single bacterium. Proc Natl Acad Sci U S A 102:9160–9164. 10.1073/pnas.0503311102 [pdf]

2003

  • Vilar JMG, Guet CC, Leibler S. 2003. Modeling network dynamics: the lac operon, a case study. J Cell Biol 161:471–476. 10.1083/jcb.200301125 [pdf]

2002

  • Guet CC, Elowitz MB, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic networks. Science 296:1466–1470. 10.1126/science.1067407 [pdf]

1996

  • Dogterom M, Félix MA, Guet CC, Leibler S. 1996. Influence of M-phase chromatin on the anisotropy of microtubule asters. J Cell Biol 133:125–140. 10.1083/jcb.133.1.125 [pdf]